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Synthesis of Two Conformationally Constrained Analogues of the Minor Tobacco Alkaloid Anabasine

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journal contribution
posted on 06.07.2000, 00:00 by Stefan Lindström, Lena Ripa, Anders Hallberg
The anabasine analogues spiro[4-azaindan-1,2‘-piperidine] (7) and spiro[6-azaindan-1,2‘-piperidine] (8) have been prepared. A series of palladium-catalyzed reactions, where an intramolecular cyclization constituted a key reaction, were utilized for the preparation of the two target compounds.

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