Synthesis of Trifluoromethylated Sultones from Alkenols Using a Copper Photoredox Catalyst

A photo-redox-catalyzed procedure for the one-step formation of sultones from α,ω-alkenols and tri­fluoro­methyl­sulfonyl chloride is described. Using [Cu­(dap)₂]Cl (1 mol %), a wide range of substrates can be cleanly converted to the target compounds, while commonly employed photoelectron transfer catalysts such as [Ru­(bpy)₃]­Cl₂ or <i>fac</i>-Ir­(ppy)₃ fail in this transformation. The obtained fluorinated sultones are attractive as potential electrolyte additives or as structural motifs in drug synthesis, with the latter being demonstrated with the synthesis of a trifluoroethyl-substituted analogue of a benzoxathiin that has high anti-arrhythmic activity.