American Chemical Society
ol5b00597_si_001.pdf (19 MB)

Synthesis of β‑Thiol Phenylalanine for Applications in One-Pot Ligation–Desulfurization Chemistry

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journal contribution
posted on 2015-05-01, 00:00 authored by Lara R. Malins, Andrew M. Giltrap, Luke J. Dowman, Richard J. Payne
The efficient synthesis of a β-thiol phenylalanine derivative is described starting from Garner’s aldehyde. The utility of this amino acid in peptide ligation–desulfurization chemistry is described, including the trifluoroethanethiol (TFET)-promoted one-pot assembly of the 62 residue peptide hormone augurin.