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Synthesis of Tetramic Acid Derivatives via Intramolecular sp3 C–H Amination Mediated by Hypervalent Iodine(III) Reagents/Brønsted Acids

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journal contribution
posted on 18.01.2013, 00:00 by Lujia Mao, Yan Li, Tao Xiong, Kai Sun, Qian Zhang
An efficient synthesis of tetramic acid derivatives was developed via intramolecular sp3 C–H aminations of 1-acetyl N-aryl cyclopropane/cyclopentanecarboxamides in the presence of PhI­(OPiv)2 and CH3CH2COOH.