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Synthesis of Tertiary Enamides by Ag2CO3‑Promoted Pd-Catalyzed Alkenylation of Acyclic Secondary Amides

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journal contribution
posted on 20.09.2016, 14:04 by Arnaud Delforge, Irene Georgiou, Adrian Kremer, Johan Wouters, Davide Bonifazi
A Pd-catalyzed methodology for the preparation of tertiary enamides from acyclic secondary amides and bromo acrylates under mild reaction conditions has been developed using [Pd2(dba)3], XantPhos, and Ag2CO3 as a base. The reaction occurs through a stereospecific metal-mediated oxidative-insertion mechanism.

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