posted on 2023-10-12, 12:08authored byXi Zou, Hanbing Wang, Bing Gao
A novel copper-catalyzed cross-coupling reaction of sulfinamides
and aryl boronic acids is developed. The reaction is highly chemoselective
and stereospecific, which allows mild synthesis of optically pure
sulfoximines with broad scope and functional group tolerance. The
utility of this method is demonstrated by the asymmetric synthesis
of pharmaceutical intermediates.