American Chemical Society
ol3c02970_si_001.pdf (10.94 MB)

Synthesis of Sulfoximines by Copper-Catalyzed Oxidative Coupling of Sulfinamides and Aryl Boronic Acids

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journal contribution
posted on 2023-10-12, 12:08 authored by Xi Zou, Hanbing Wang, Bing Gao
A novel copper-catalyzed cross-coupling reaction of sulfinamides and aryl boronic acids is developed. The reaction is highly chemoselective and stereospecific, which allows mild synthesis of optically pure sulfoximines with broad scope and functional group tolerance. The utility of this method is demonstrated by the asymmetric synthesis of pharmaceutical intermediates.