jo900693a_si_001.pdf (3.83 MB)
Synthesis of Substituted Pyrrolin-4-ones from Amino Acids in Mild Conditions via a Gold-Catalyzed Approach
journal contributionposted on 2009-08-07, 00:00 authored by Nicolas Gouault, Myriam Le Roch, Carole Cornée, Michèle David, Philippe Uriac
The gold-catalyzed cyclization of various α-amino-ynone derivatives gave the corresponding pyrrolin-4-ones in high yields. Moreover, the use of gold(III) oxide as catalyst allows a moderate to total stereocontrol during the cyclization. These pyrrolin-4-ones are highly useful intermediates for the synthesis of functionalized pyrrolidines and other natural products.