Synthesis of Pyrido[1,2-a]indole Malonates and Amines through Aryne Annulation
journal contributionposted on 16.03.2012, 00:00 by Donald C. Rogness, Nataliya A. Markina, Jesse P. Waldo, Richard C. Larock
Pyrido[1,2-a]indoles are known as medicinally and pharmaceutically important compounds, but there is a lack of efficient methods for their synthesis. We report a convenient and efficient route to these privileged structures starting from easily accessible 2-substituted pyridines and aryne precursors. A small library of compounds has been synthesized utilizing the developed method, affording variously substituted pyrido[1,2-a]indoles in moderate to good yields.