ol203055v_si_002.pdf (12.66 MB)

Synthesis of Propargylic and Allenic Carbamates via the C–H Amination of Alkynes

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journal contribution
posted on 22.02.2016, 10:06 by R. David Grigg, Jared W. Rigoli, Simon D. Pearce, Jennifer M. Schomaker
Propargylic amines are important intermediates for the synthesis of nitrogen-containing heterocycles. The insertion of a nitrene into a propargylic C–H bond has not been explored, despite the attention directed toward the Rh-catalyzed amination of other types of C–H bonds. In this communication, the conversion of a series of homopropargylic carbamates to propargylic carbamates and aminated allenes is described.