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Synthesis of Polysubstituted Cyclopentenones via [4+1] Reactions of TIPS-Vinylketenes

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journal contribution
posted on 21.12.2007, 00:00 by Zhi Li, William H. Moser, Ruixue Deng, Liangdong Sun
An efficient method for preparing a series of polysubstituted cyclopentenones from TIPS-vinylketenes and Köbrich reagent has been developed in this paper. Additionally, highly substituted cyclopentenones can be prepared via [4+1] reaction of TIPS-vinylketenes with tert-butyl isocyanide and there is a remarkable preference for formation of products with an exocyclic (Z)-imine moiety.