Synthesis of Polycarbonyl Pyrroles via K₂S₂O₈‑Mediated Oxidative Cyclization of Enamines

A novel K₂S₂O₈-promoted oxidative cyclization of enamines is described. A variety of enamines having diverse functional groups and substitution patterns react well using K₂S₂O₈ as the oxidant in the absence of catalyst. This protocol provides a very simple route for the synthesis of polycarbonyl pyrroles and has the advantages of readily available starting materials, mild reaction conditions, and a wide scope of substrates.