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Synthesis of Orthogonally Protected Disulfide Bridge Mimetics

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journal contribution
posted on 21.01.2011, 00:00 by Andrew C. Tadd, Kristian Meinander, Kristina Luthman, Erik A. A. Wallén
Concise routes to four orthogonally protected, enantiopure disulfide bridge mimetics are reported. These four dicarba analogues possess an alkyne, an (E)-alkene, a (Z)-alkene, and an alkane as substitutes for the disulfide bridge. Selective deprotection of one of these mimetics is also illustrated.