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Synthesis of Oligomers Derived from Amide-Linked Neuraminic Acid Analogues#

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journal contribution
posted on 20.02.2004, 00:00 by Travis Q. Gregar, Jacquelyn Gervay-Hague
N-Fluoren-9-ylmethoxycarbonyl-protected sugar amino acids derived from α-O-methoxy- and 2,3-dehydroneuraminic acids have been prepared. Incorporation of these monomer units into solid-phase synthesis led to the efficient synthesis of two series of oligomers varying from one to eight units in length. The (1→5)-linked amides of 2,3-dehydroneuraminic acid were further subjected to hydrogenation giving a third series of oligomers with a β-hydrido substituent at the anomeric carbon.