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Synthesis of Novel S-Neoglycopeptides from Glycosylthiomethyl Derivatives

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journal contribution
posted on 01.04.2004, 00:00 by Xiangming Zhu, Kandasamy Pachamuthu, Richard R. Schmidt
Reaction of glycosylthiomethyl azides with amino acid and peptide derivatives containing aspartate and glutamate thio acids gave the corresponding glycosylthiomethyl amides in excellent yields. Another type of neoglycopeptides was obtained via reaction of glycosylthiomethyl bromide with cysteine and homocysteine containing peptide derivatives, thus affording the corresponding S-(glycosylthiomethyl) peptides.