posted on 2012-06-14, 00:00authored byKeith
ó Proinsias, Maciej Giedyk, Iraida G. Sharina, Emil Martin, Dorota Gryko
Herein, the synthesis of novel hydrophobic and hydrophilic
cobinamides
via aminolysis of vitamin B12 derivatives that activate
soluble guanyl cyclase (sGC) is presented. Unlike other sGC regulators,
they target the catalytic domain of sGC and show higher activity than
(CN)2Cbi.