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Synthesis of New Hydrophilic and Hydrophobic Cobinamides as NO-Independent sGC Activators

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journal contribution
posted on 2012-06-14, 00:00 authored by Keith ó Proinsias, Maciej Giedyk, Iraida G. Sharina, Emil Martin, Dorota Gryko
Herein, the synthesis of novel hydrophobic and hydrophilic cobinamides via aminolysis of vitamin B12 derivatives that activate soluble guanyl cyclase (sGC) is presented. Unlike other sGC regulators, they target the catalytic domain of sGC and show higher activity than (CN)2Cbi.