Synthesis of New Hydrophilic
and Hydrophobic Cobinamides
as NO-Independent sGC Activators

Proinsias, Keith
ó; Giedyk, Maciej; Sharina, Iraida G.; Martin, Emil; Gryko, Dorota

doi:10.1021/ml300060n.s001

ml300060n_si_001.pdf (4.5 MB)

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Synthesis of New Hydrophilic and Hydrophobic Cobinamides as NO-Independent sGC Activators

journal contribution

posted on 2012-06-14, 00:00 authored by Keith ó Proinsias, Maciej Giedyk, Iraida G. Sharina, Emil Martin, Dorota Gryko

Herein, the synthesis of novel hydrophobic and hydrophilic cobinamides via aminolysis of vitamin B₁₂ derivatives that activate soluble guanyl cyclase (sGC) is presented. Unlike other sGC regulators, they target the catalytic domain of sGC and show higher activity than (CN)₂Cbi.