ml300060n_si_001.pdf (4.5 MB)
Download fileSynthesis of New Hydrophilic and Hydrophobic Cobinamides as NO-Independent sGC Activators
journal contribution
posted on 2012-06-14, 00:00 authored by Keith
ó Proinsias, Maciej Giedyk, Iraida G. Sharina, Emil Martin, Dorota GrykoHerein, the synthesis of novel hydrophobic and hydrophilic
cobinamides
via aminolysis of vitamin B12 derivatives that activate
soluble guanyl cyclase (sGC) is presented. Unlike other sGC regulators,
they target the catalytic domain of sGC and show higher activity than
(CN)2Cbi.