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Synthesis of New DPP‑4 Inhibitors Based on a Novel Tricyclic Scaffold

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journal contribution
posted on 12.03.2015, 00:00 by Carolin Schwehm, Jin Li, Hongmei Song, Xiao Hu, Barrie Kellam, Michael J. Stocks
A novel molecular scaffold has been synthesized, and its synthesis and incorporation into new analogues of biologically active molecules will be discussed. A comparison of the inhibitory activity of these compounds to the known type-2 diabetes compound (sitagliptin) against dipeptidyl peptidase-4 (DPP-4) will be shown.