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Synthesis of Metal–Organic Frameworks MIL-101(Cr)‑NH2 Containing Phosphorous Acid Functional Groups: Application for the Synthesis of N‑Amino-2-pyridone and Pyrano [2,3‑c]pyrazole Derivatives via a Cooperative Vinylogous Anomeric-Based Oxidation

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journal contribution
posted on 20.03.2020, 13:34 by Saeed Babaee, Mahmoud Zarei, Hassan Sepehrmansourie, Mohammad Ali Zolfigol, Sadegh Rostamnia
In the current paper, we successfully developed and used metal–organic frameworks (MOFs) based on MIL-101­(Cr)-NH2 with phosphorus acid functional groups MIL-101­(Cr)-N­(CH2PO3H2)2. The synthesized metal–organic frameworks (MOFs) as a multi-functional heterogeneous and nanoporous catalyst were used for the synthesis of N-amino-2-pyridone and pyrano [2,3-c]­pyrazole derivatives via reaction of ethyl cyanoacetate or ethyl acetoacetate, hydrazine hydrate, malononitrile, and various aldehydes. The final step of the reaction mechanism was preceded by a cooperative vinylogous anomeric-based oxidation. Recycle and reusability of the described catalyst MIL-101­(Cr)-N­(CH2PO3H2)2 were also investigated.