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Synthesis of Lipophilic Aldehydes and Study of Their Inhibition Effect on Human Digestive Lipases

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journal contribution
posted on 13.07.2002, 00:00 by Stavroula Kotsovolou, Robert Verger, George Kokotos
Novel inhibitors of human digestive lipases, aldehyde dialkyl and alkyl-acyl glycerol analogues, were developed. The inhibitors were prepared starting from 3-(benzyloxy)-1,2-propanediol. The inhibition of human pancreatic and gastric lipases by the aldehyde derivatives was studied using the monolayer technique. (1R)-1-[(Dodecyloxy)methyl]-4-oxobutyl decanoate caused a 50% decrease in HPL and HGL activities at 0.100 and 0.053 molar fractions, respectively.