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Synthesis of Highly Fluorinated 2,2′-Biphenols and 2,2′-Bisanisoles

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journal contribution
posted on 2010-10-01, 00:00 authored by Robert Francke, Gregor Schnakenburg, Siegfried R. Waldvogel
Multiply fluorine-substituted iodo anisoles are efficiently coupled in an Ullmann-type reaction to provide the corresponding bisanisoles. The coupling is selective and even tolerates bromo moieties. Subsequent deprotection of hydroxy groups gives access to highly fluorinated biphenols.

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