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Synthesis of ω-(Hetero)arylalkynylated α-Amino Acid by Sonogashira-Type Reactions in Aqueous Media

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posted on 2006-09-29, 00:00 authored by Roberto J. Brea, M. Pilar López-Deber, Luis Castedo, Juan R. Granja
Mild conditions are described that allow the palladium-catalyzed cross-coupling of Cα-alkynylated glycine with a wide variety of electron-rich and electron-poor aryl and heteroaryl halides in aqueous media.

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    The Journal of Organic Chemistry

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