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Synthesis of Fused Imidazole-Containing Ring Systems via Dual Oxidative Amination of C(sp3)–H Bonds

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journal contribution
posted on 16.08.2016, 00:00 by Georgette Castanedo, Yanzhou Liu, James J. Crawford, Marie-Gabrielle Braun
A general and efficient method for a metal-free one-pot synthesis of highly substituted fused imidazole-containing 5,5- and 5,6-fused bicyclic heterocycles is described. Starting from commercially available substrates and reagents, the reaction proceeds through two C–N bond formations and an oxidative dehydrogenation to form highly substituted products in good to excellent yield.