posted on 2017-10-09, 14:18authored byGuang Chen, Ze Wang, Xinying Zhang, Xuesen Fan
In
this paper, a novel and efficient synthesis of 3-acylpyridines
and pyridine-3-carboxylates through the oxidative one-pot sequential
reactions of inactivated saturated ketones with electron-deficient
enamines is presented. Mechanistically, the formation of the title
compounds involves the in situ formation of an enone intermediate
through an oxidative dehydrogenation of the saturated ketone substrate,
followed by its [3+3] annulation with β-enaminone or β-enaminoester
via a cascade process, including Michael addition, aldol type condensation,
and oxidative aromatization.