American Chemical Society
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Synthesis of Functionalized Oxazoles via Silver-Catalyzed Cyclization of Propargylamides and Allenylamides

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journal contribution
posted on 2013-08-02, 00:00 authored by Yancheng Hu, Ruxia Yi, Fan Wu, Boshun Wan
Silver­(I)-catalyzed [3,3] rearrangement of N-sulfonyl propargylamides affords functionalized oxazoles with highly regioselective migration of the sulfonyl group by the introduction of acyloxy groups. The allenylamides, generated from the corresponding propargylamides, can also undergo the silver-catalyzed cyclization to give various 5-vinyloxazoles.