American Chemical Society
ol2c00969_si_001.pdf (4.15 MB)

Synthesis of α‑Fluorinated Areneacetates through Photoredox/Copper Dual Catalysis

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journal contribution
posted on 2022-04-25, 21:08 authored by Guillaume Levitre, Albert Granados, María Jesús Cabrera-Afonso, Gary A. Molander
The development of mild and practical conditions for the fluoroalkylation of arenes is an ongoing challenge in chemical organic synthesis. Herein, we report a metallaphotoredox method for the preparation of fluoroalkyl arenes based on the synergistic combination of Ir/Cu dual catalysis from boronic acids. The mild conditions allow broad functional group tolerance, including substrates containing aldehydes, free phenols, and N-Boc-protected amines. Mechanistic investigations support a process proceeding via photoredox/copper dual catalysis.