American Chemical Society
ol025988b_si_001.pdf (2.95 MB)

Synthesis of Cyclic (α2β)-Tripeptides as Potential Peptide Turn Mimetics

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journal contribution
posted on 2002-06-04, 00:00 authored by Bas Wels, John A. W. Kruijtzer, Rob M. J. Liskamp
The solid-supported synthesis followed by cyclization in solution of cyclic (α2β)-tripeptides, potential peptide β-turn mimetics, is described. The cyclization takes advantage of facilitating the rotation between trans- and cis-rotamers of two amide bonds. The method is amenable to combinatorial approaches as is illustrated by the synthesis of a small array of cyclic (α2β)-tripeptides.