posted on 2002-06-04, 00:00authored byBas Wels, John A. W. Kruijtzer, Rob M. J. Liskamp
The solid-supported synthesis followed by cyclization in solution of cyclic (α2β)-tripeptides, potential peptide β-turn mimetics, is described.
The cyclization takes advantage of facilitating the rotation between trans- and cis-rotamers of two amide bonds. The method is amenable to
combinatorial approaches as is illustrated by the synthesis of a small array of cyclic (α2β)-tripeptides.