American Chemical Society
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Synthesis of Cyclic Imides from Nitriles and Diols Using Hydrogen Transfer as a Substrate-Activating Strategy

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journal contribution
posted on 2014-09-05, 00:00 authored by Jaewoon Kim, Soon Hyeok Hong
An atom-economical and versatile method for the synthesis of cyclic imides from nitriles and diols was developed. The method utilizes a Ru-catalyzed transfer-hydrogenation reaction in which the substrates, diols, and nitriles are simultaneously activated into lactones and amines in a redox-neutral manner to afford the corresponding cyclic imides with evolution of H2 gas as the sole byproduct. This operationally simple and catalytic synthetic method provides a sustainable and easily accessible route to cyclic imides.