ol7b02271_si_001.pdf (14.3 MB)
Synthesis of Chondroitin Sulfate A Bearing Syndecan‑1 Glycopeptide
journal contribution
posted on 2017-08-29, 11:34 authored by Sherif Ramadan, Weizhun Yang, Zeren Zhang, Xuefei HuangSyndecan-1
chondroitin sulfate glycopeptide was synthesized for the first time
using the cassette approach. The sequence of glycosylation to form
the octasaccharide serine cassette was critical. The glycopeptide
was successfully assembled via a 2+ (3 + 3) glycosylation strategy
followed by peptide chain elongation.