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Synthesis of Chiral N-Heterocyclic Carbene Ligands with Rigid Backbones and Application to the Palladium-Catalyzed Enantioselective Intramolecular α-Arylation of Amides

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journal contribution
posted on 2011-04-01, 00:00 authored by Lantao Liu, Naoki Ishida, Shinji Ashida, Masahiro Murakami
Chiral N-heterocyclic carbene (NHC) ligands having a 2,2′-bisquinoline-based C2 symmetric skeleton were developed. The ligands exhibited good enantioselectivity in palladium-catalyzed intramolecular α-arylation of amides to give 3,3-disubsituted oxindoles.

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