cs5b01641_si_001.pdf (5.33 MB)
Download file

Synthesis of Chiral Trifluoromethyl-Substituted Hydrazines via Pd-Catalyzed Asymmetric Hydrogenation and Reductive Amination

Download (5.33 MB)
journal contribution
posted on 02.10.2015, 00:00 by Zhang-Pei Chen, Shu-Bo Hu, Ji Zhou, Yong-Gui Zhou
An efficient approach toward the synthesis of cyclic and linear chiral trifluoromethyl substituted hydrazines was developed by Pd-catalyzed asymmetric hydrogenation of both N-acyl and N-aryl hydrazones in excellent yields and up to 97% ee. A successful reductive amination between trifluoromethyl substituted ketones and hydrazines was also achieved.