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Synthesis of Catechins via Thiourea/AuCl3-Catalyzed Cycloalkylation of Aryl Epoxides

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posted on 2008-06-20, 00:00 authored by Yongxiang Liu, Xiben Li, Guang Lin, Zheng Xiang, Jing Xiang, Mingzhe Zhao, Jiahua Chen, Zhen Yang
A diversity-oriented approach for the synthesis of structurally diverse catechins was achieved in good yields via thiourea/AuCl3/AgOTf-catalyzed annulations of aryl epoxides under mild conditions. This new protocol provides a highly efficient entry to a library of catechins-derived natural products, notably anti-HIV agent 8-C-ascorbyl-(−)-epigallocatechin.

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    The Journal of Organic Chemistry

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