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Synthesis of α-CN and α-CF3 N-Heterocycles through Tandem Nucleophilic Additions

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journal contribution
posted on 01.07.2011, 00:00 by Junbin Han, Bo Xu, Gerald B. Hammond
Using a readily available secondary aminoalkyne as starting material, a powerful strategy was discovered to prepare precursors of biologically important unnatural cyclic aminoacids and fluorinated N-heterocycles with important ring sizes (e.g., 5–7) in a one-pot reaction using two nucleophilic additions in a tandem fashion.