Synthesis of CF₃CH₂‑Containing Indolines by Transition-Metal-Free Aryltrifluoro­methylation of Unactivated Alkenes

With an unactivated double bond as the radical acceptor, allyl amines underwent a metal-free trifluoromethylation/cyclization cascade with CF₃SO₂Na (Langlois’ reagent), affording CF₃CH₂-containing indolines and tetrahydro­isoquinolines, whose practical syntheses are significant challenges. This protocol features mild conditions, low cost, and a broad substrate scope.