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Synthesis of Biologically Active Amines via Rhodium−Bisphosphite-Catalyzed Hydroaminomethylation

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journal contribution
posted on 27.10.2005, 00:00 by John R. Briggs, Jerzy Klosin, Gregory T. Whiteker
We report the use of a highly regioselective rhodium−bisphosphite catalyst for olefin hydroaminomethylation. This catalyst system was successfully applied in the synthesis of two biologically active tertiary amines, ibutilide and aripiprazole.