jo4011409_si_001.pdf (1.26 MB)
Download fileSynthesis of Azomethine Imines Using an Intramolecular Alkyne Hydrohydrazination Approach
journal contribution
posted on 2013-09-06, 00:00 authored by Ashley
D. Hunt, Isabelle Dion, Nicolas Das Neves, Sandrine Taing, André M. BeaucheminAzomethine
imines can be accessed upon heating appropriate alkynylhydrazide precursors.
This simple thermal hydroamination approach allows the formation of
five- and six-membered dipoles in modest to excellent yields. The
structure of the acyl group is important to minimize side reactions
and allow the isolation of the azomethine imines by column chromatography.