Synthesis of Aza-Eight-Membered Ring-Fused Indolines Initiated by Zn-Catalyzed C2 Alkylation of Indoles and Subsequent Base-Promoted Ring Expansion
journal contributionposted on 06.08.2020 by Yang Yuan, Ye Wang, Yuanyang Mu, Murong Xu, Siyi Fu, Lingkai Kong, Yanzhong Li
Any type of content formally published in an academic journal, usually following a peer-review process.
A novel and efficient synthesis of aza-eight-membered ring-fused indolines has been developed. This process is realized by zinc-catalyzed C2 alkylation of indoles and subsequent base-promoted ring expansion of the newly formed six-membered ring with alkynes. Easily accessible starting materials, good functional group tolerance, and high atom economy make this procedure attractive.