ol0c02307_si_001.pdf (14.34 MB)
Synthesis of Aza-Eight-Membered Ring-Fused Indolines Initiated by Zn-Catalyzed C2 Alkylation of Indoles and Subsequent Base-Promoted Ring Expansion
journal contribution
posted on 2020-08-06, 22:20 authored by Yang Yuan, Ye Wang, Yuanyang Mu, Murong Xu, Siyi Fu, Lingkai Kong, Yanzhong LiA novel and efficient synthesis of
aza-eight-membered ring-fused
indolines has been developed. This process is realized by zinc-catalyzed
C2 alkylation of indoles and subsequent base-promoted ring expansion
of the newly formed six-membered ring with alkynes. Easily accessible
starting materials, good functional group tolerance, and high atom
economy make this procedure attractive.