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Synthesis of Antimicrobial Natural Products Targeting FtsZ:  (±)-Dichamanetin and (±)-2‘ ‘‘-Hydroxy-5‘ ‘-benzylisouvarinol-B

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journal contribution
posted on 08.12.2005, 00:00 by Sameer Urgaonkar, Henry S. La Pierre, Israel Meir, Henrik Lund, Debabrata RayChaudhuri, Jared T. Shaw
Two natural products have been synthesized using a ZnCl2-mediated benzylic coupling reaction. Both are potent inhibitors of the GTPase activity of FtsZ, a highly conserved protein that is essential for bacterial cytokinesis.