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Synthesis of Annulated γ-Carbolines by Palladium-Catalyzed Intramolecular Iminoannulation

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journal contribution
posted on 15.08.2002, 00:00 by Haiming Zhang, Richard C. Larock
A variety of N-substituted 2-bromo-1H-indole-3-carboxaldehydes incorporating an alkyne-containing tether on the indole nitrogen have been converted to the corresponding tert-butylimines, which have been subjected to palladium-catalyzed intramolecular iminoannulation, affording various annulated γ-carbolines in excellent yields.