American Chemical Society
ol200287z_si_001.pdf (1.36 MB)

Synthesis of β-Amino Acid Derivatives via Copper-Catalyzed Asymmetric 1,4-Reduction of β-(Acylamino)acrylates

Download (1.36 MB)
journal contribution
posted on 2011-04-01, 00:00 authored by Yan Wu, Shan-Bin Qi, Fei-Fei Wu, Xi-Chang Zhang, Min Li, Jing Wu, Albert S. C. Chan
A new set of reaction conditions has been established to facilitate the copper-catalyzed enantioselective 1,4-reduction of β-(acylamino)acrylates toward a selection of β-alkyl-β-amino acid derivatives in high yields and with uniformly high ee values (up to 99%) irrespective of the use of (E)- or (Z)-substrates.