Synthesis of β-Amino Acid Derivatives via Copper-Catalyzed Asymmetric 1,4-Reduction of β-(Acylamino)acrylates

Wu, Yan; Qi, Shan-Bin; Wu, Fei-Fei; Zhang, Xi-Chang; Li, Min; Wu, Jing; S. C. Chan, Albert

doi:10.1021/ol200287z.s001

ol200287z_si_001.pdf (1.36 MB)

Synthesis of β-Amino Acid Derivatives via Copper-Catalyzed Asymmetric 1,4-Reduction of β-(Acylamino)acrylates

journal contribution

posted on 2011-04-01, 00:00 authored by Yan Wu, Shan-Bin Qi, Fei-Fei Wu, Xi-Chang Zhang, Min Li, Jing Wu, Albert S. C. Chan

A new set of reaction conditions has been established to facilitate the copper-catalyzed enantioselective 1,4-reduction of β-(acylamino)acrylates toward a selection of β-alkyl-β-amino acid derivatives in high yields and with uniformly high ee values (up to 99%) irrespective of the use of (E)- or (Z)-substrates.