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Synthesis of 5-epi-Taiwaniaquinone G

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journal contribution
posted on 2014-07-03, 00:00 authored by Jinqian Wang, Jing Wang, Changwei Li, Yonggang Meng, Jie Wu, Chuanjun Song, Junbiao Chang
A concise synthetic approach to the unnatural 5-epi-taiwaniaquinone G has been developed via a Lewis acid catalyzed tandem acylation–Nazarov cyclization reaction to construct the tricyclic skeleton, followed by installation of the isopropyl group through a strategy involving coumarin formation and its subsequent hydrolysis.

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