Synthesis of 4‑Isoxazolines through Gold(I)-Catalyzed Cyclization of Propargylic <i>N</i>‑Hydroxylamines

New catalytic methods for the synthesis of 4-isoxazolines have been developed via catalytic intramolecular cyclizations of propargylic <i>N</i>-hydroxylamines. The reactions proceed rapidly in less than 1 h at room temperature in the presence of 5 mol % (PPh₃)­AuCl/5 mol % AgOTf or 5 mol % (PPh₃)­AuNTf₂. This process features an efficient route to 4-isoxazolines with high yields, short reaction times, and mild reaction conditions.