American Chemical Society
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Synthesis of 4-Trifluoromethylated 2-Alkyl- and 2,3-Dialkyl-Substituted Azetidines

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journal contribution
posted on 2003-10-03, 00:00 authored by Jinlong Jiang, Hemal Shah, Robert J. DeVita
A diastereoselective approach to the synthesis of 4-trifluoromethylated 2-alkyl- and 2,3-dialkylazetidines, including BOC-protected 4-trifluoromethylazetidin-2-ylcarboxylic acid, was developed via Wittig reaction of 4-trifluomethylated β-lactam followed by alkylation and hydrogenation.