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Synthesis of 3‑Trifluoromethyl-1,2,4-triazolines and 1,2,4-Triazoles via Tandem Addition/Cyclization of Trifluoromethyl N‑Acylhydrazones with Cyanamide

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journal contribution
posted on 12.04.2022, 19:07 authored by Xiaoling Liu, Haimei Liu, Chang Bian, Ke-Hu Wang, Junjiao Wang, Danfeng Huang, Yingpeng Su, Xiaobo Lv, Yulai Hu
A tandem addition/cyclization reaction between trifluoromethyl N-acylhydrazones and cyanamide is described, which provides a novel and efficient process for the synthesis of polysubstituted 3-trifluoromethyl-1,2,4-triazolines and their derivatives. The method has the advantages of mild reaction conditions, a broad substrate scope, good product yields, and atom economy.