jo1c01851_si_001.pdf (1.59 MB)
Download file

Synthesis of 3,3-Dihalogenated 2‑Aminochromanones via Tandem Dihalogenation and Cyclization of o‑Hydroxyarylenaminones with NXS (X = Cl or Br)

Download (1.59 MB)
journal contribution
posted on 2021-10-14, 06:13 authored by Tian Luo, Haozhi Wu, Li-hua Liao, Jie-Ping Wan, Yunyun Liu
An unprecedented method for the synthesis of dichlorinated and dibrominated 2-amino-substituted chromanones is developed by employing enaminones and NCS/NBS as starting materials under microwave irradiation. The reactions proceed quickly to deliver products without using any catalyst or additive, thus providing practical access to 3,3-dihalogenated 2-aminochromanones.