Synthesis of 3,3-Dihalogenated 2‑Aminochromanones via Tandem Dihalogenation and Cyclization of o‑Hydroxyarylenaminones with NXS (X = Cl or Br)

An unprecedented method for the synthesis of dichlorinated and dibrominated 2-amino-substituted chromanones is developed by employing enaminones and NCS/NBS as starting materials under microwave irradiation. The reactions proceed quickly to deliver products without using any catalyst or additive, thus providing practical access to 3,3-dihalogenated 2-aminochromanones.