Synthesis of {323}-p-Octiphenyls:  Orthogonal Functionalization along a Rigid-Rod Scaffold for Refined Supramolecular Architecture

The synthesis of p-octiphenyls carrying orthogonal tert-butyl esters in the peripheral positions 1², 2², 3³, 6², 7³, and 8² and either p-methoxybenzyl or benzyl ester substituents in the central positions 4² and 5³ is described. Resolution-enhanced HSQC/HMBC two-dimensional NMR spectroscopy is implemented as an attractive method for the complete characterization of complex p-oligophenyl scaffolds.