ol8006315_si_001.pdf (4.98 MB)
Synthesis of (2-Oxoindolin-3-ylidene)methyl Acetates Involving a C−H Functionalization Process
journal contribution
posted on 2008-05-01, 00:00 authored by Shi Tang, Peng Peng, Zhi-Qiang Wang, Bo-Xiao Tang, Chen-Liang Deng, Jin-Heng Li, Ping Zhong, Nai-Xing WangA novel palladium-catalyzed oxidative C−H functionalization protocol for the synthesis of (2-oxoindolin-3-ylidene)methyl acetates has been developed. In the presence of Pd(OAc)2 and PhI(OAc)2, a variety of N-arylpropiolamides underwent the C−H functionalization reaction with acids to afford the corresponding (E)-(2-oxoindolin-3-ylidene)methyl acetates selectively in moderate to excellent yields.
