jo400913k_si_001.pdf (10.85 MB)
Download fileSynthesis of 2′-Deoxy-9-deaza Nucleosides Using Heck Methodology
journal contribution
posted on 19.07.2013, 00:00 authored by Kartik Temburnikar, Kelin Brace, Katherine L. Seley-RadtkeDuring
the synthesis of a series of 2′-deoxy-9-deaza nucleosides
using Heck methodology, the necessity for a pyrrole protecting group
was discovered. The results of this brief study revealed that the
benzyloxymethyl (BOM) group proved optimal, and Heck coupling using
Jeffery conditions increased the coupling yield significantly. The
results are reported herein.