Synthesis of 2′-Deoxy-9-deaza Nucleosides Using Heck Methodology
journal contributionposted on 19.07.2013, 00:00 by Kartik Temburnikar, Kelin Brace, Katherine L. Seley-Radtke
During the synthesis of a series of 2′-deoxy-9-deaza nucleosides using Heck methodology, the necessity for a pyrrole protecting group was discovered. The results of this brief study revealed that the benzyloxymethyl (BOM) group proved optimal, and Heck coupling using Jeffery conditions increased the coupling yield significantly. The results are reported herein.