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Synthesis of 2-C-Methyl-d-erythritol 4-Phosphate:  The First Pathway-Specific Intermediate in the Methylerythritol Phosphate Route to Isoprenoids

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journal contribution
posted on 28.12.1999, 00:00 by Andrew T. Koppisch, Brian S. J. Blagg, C. Dale Poulter
2-C-Methyl-d-erythritol 4-phosphate (4), formed from 1-deoxy-d-xylulose 5-phosphate (3), is the first pathway-specific intermediate in the methylerythritol phosphate route for the biosynthesis of isoprenoid compounds in bacteria, algae, and plant chloroplasts. In this report, 4 was synthesized from 1,2-propanediol (7) in seven steps with an overall yield of 32% and in an enantiomeric excess of 78%.