ol020158j_si_002.pdf (140.4 kB)
Synthesis of 1,3-Difluoroaromatics in One Pot by Addition of Difluorocarbene from Sodium Chlorodifluoroacetate to 1,2-Substituted Cyclobutenes
journal contribution
posted on 2002-10-08, 00:00 authored by Heather M. Morrison, James E. Rainbolt, Scott B. LewisThe synthesis of 1,3-difluoro-2,4-diphenylbenzene has been accomplished in one step from 1,2-diphenylcyclobutene using the environmentally
benign difluorocarbene precursor sodium chlorodifluoroacetate. In addition, the preparation of the previously unknown compound 1,3-difluoro-2,4-di-n-propylbenzene has been accomplished in one step from 1,2-di-n-propylcyclobutene using Seyferth's reagent (Ph−Hg−CF3) and sodium
chlorodifluoroacetate.