ol0273405_si_001.pdf (672.57 kB)
Synthesis of (−)-TAN-2483A. Revision of the Structures and Syntheses of (±)-FD-211 (Waol A) and (±)-FD-212 (Waol B)
journal contributionposted on 2003-01-30, 00:00 authored by Xiaolei Gao, Masakazu Nakadai, Barry B. Snider
The structure of waol A has been revised from 1 to 6, the vinylogue of TAN-2483 A (5). Aldol reaction of 10b(c) with 2,4-hexadienal (11) affords 9b(c), which is subjected to iodoetherification with bis(sym-collidine)IPF6 to provide 8b(c). Treatment with Et3N in CH2Cl2 completes three-step syntheses of TAN-2483A (5) and waol A (6).