American Chemical Society
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Synthesis of β-Lactones by the Regioselective, Cobalt and Lewis Acid Catalyzed Carbonylation of Simple and Functionalized Epoxides

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journal contribution
posted on 2001-07-19, 00:00 authored by Jong Tae Lee, P. J. Thomas, Howard Alper
The PPNCo(CO)4 and BF3·Et2O catalyzed carbonylation of simple and functionalized epoxides in DME gives the corresponding β-lactones regioselectively in good to high yields. The carbonylation occurred selectively at the unsubstituted C−O bond of the epoxide ring, and this reaction tolerates various functional groups such as alkenyl, halide, hydroxy, and alkyl ether.